|
|
Phytoextraction of metformin and guanylurea
Kovářová, Kristýna ; Smrček, Stanislav (advisor) ; Petrová, Šárka (referee)
Pharmaceutically Active Compounds include metformin, the most often prescripted drug for a treatment of the diabetes mellitus type 2. Metformin is used in high daily doses (up to 3000 mg per day) and it is eliminated by kidneys in its original non - metabolized form. Metformin is degraded in the wastewater treatment plants to guanylurea. The wastewater treatment plants aren't able to clean the waste water, so metformin and guanylurea enter the environment, especially surface water. This diploma thesis deals with the ability to remove metformin and its environmental metabolite guanylurea via phytoextraction technologies. First experiment was focused on phytoextraction of metformin using 5 plant species - Zea mays L., Pisum sativum L., Avena sativa L., Alternanthera reineckii Mini L. and Staurogyne repens L. Second experiment studied phytoextraction of guanylurea using Zea mays L. and Pisum sativum L. The third experiment deals with the phytoextraction of metformin and guanylurea together using Zea mays L. The media of all plants were contaminated by metformin or guanylurea at different concentration levels. The samples of media were taken in 24 hours intervals during the plant cultivation and the decrease of its concentration were studied by HPLC with UV detection at 233 nm for metformin and 210 nm...
|
|
|
Krystalové inženýrství nových materialů pro nelineární optiku
Fridrichová, Michaela ; Němec, Ivan (advisor) ; Černošek, Zdeněk (referee) ; Schwendt, Peter (referee)
This thesis focuses on preparation of novel compounds suitable for nonlinear optics (NLO). In particular, the target property is the second harmonic generation (SHG) and the group of interest are salts of the cations with delocalized electrons which can serve as carriers of the NLO properties. In particular, four derivatives of the highly interesting molecule of guanidine were selected and their NLO potential was proven by quantum chemical computations. In total, twenty new structures were described and those with the noncentrosymmetric structure assembly were examined for the SHG efficiency. Four of the prepared compounds exhibited a noticeable SHG efficiency, two of them even comparable to urea. The most promising compound, the guanylurea hydrogen phosphite (GUHP), was examined in more detail while many interesting NLO properties were revealed. The results of this work are presented also in 10 attached publications which are an integral part of the thesis. Keywords: nonlinear optics, second harmonic generation, guanidine derivatives, guanylurea, N-phenylbiguanide, N,N-dimethylbiguanide, N,N,N˝-triphenylguanidine
|
guest ::
